A full-stack web framework such as Django gives ready-to-use solutions with its batteries-included approach, while Flask offers abundant features without external libraries.
While Django uses an object-oriented approach that enables object-relational mapping, Flask uses a modular approach that allows working with extensions and outsourced libraries.
Django comes with an in-built bootstrapping tool called Django-admin, which allows you to create web applications without any external input, whereas Flask does not.
Django supports popular RDBMS like MySQL, Oracle, etc., whereas Flask does not support the basic database management system and uses SQLAlchemy for database requirements.
Flask allows developers to create applications without requiring external libraries, whereas Django lacks full control over modules and functions due to built-in libraries.